Ra. Margni et Ac. Zenclussen, During pregnancy, in the context of a Th2-type cytokine profile, serum IL-6 levels might condition the quality of the synthesized antibodies, AM J REPROD, 46(3), 2001, pp. 181-187
PROBLEM: In recent years, the central role of cytokines in the immune respo
nse has been widely studied. It is considered that a T helper (Th)1-type cy
tokine profile is associated with the rejection phenomenon, whereas a Th2-t
ype cytokine profile is associated with immunological tolerance. In pregnan
cy, the enhanced Th2/Th1 ratio seems to be necessary to fetal protection. T
aking into account that a Th2-type response means antibody production by B
cells, and that these antibodies could induce degradation of the paternal a
ntigens, we investigated the quality of the antibodies produced during preg
nancy and their regulation.
METHOD OF STUDY: Review of previous data.
RESULTS: The regulation of protective antibodies by IL-6 in a dose-dependen
t fashion is proposed as a hypothesis.
CONCLUSION: Cytokines play a central role in the success (or failure) of pr
egnancy. However, the quality of the synthesized antibodies is also a regul
atory key. The preferential synthesis of asymmetric immunoglobulin G antibo
dies during pregnancy could be one of the several pathways that lead to a s