During pregnancy, in the context of a Th2-type cytokine profile, serum IL-6 levels might condition the quality of the synthesized antibodies

Citation
Ra. Margni et Ac. Zenclussen, During pregnancy, in the context of a Th2-type cytokine profile, serum IL-6 levels might condition the quality of the synthesized antibodies, AM J REPROD, 46(3), 2001, pp. 181-187
Citations number
40
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology
Journal title
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
ISSN journal
1046-7408 → ACNP
Volume
46
Issue
3
Year of publication
2001
Pages
181 - 187
Database
ISI
SICI code
1046-7408(200109)46:3<181:DPITCO>2.0.ZU;2-S
Abstract
PROBLEM: In recent years, the central role of cytokines in the immune respo nse has been widely studied. It is considered that a T helper (Th)1-type cy tokine profile is associated with the rejection phenomenon, whereas a Th2-t ype cytokine profile is associated with immunological tolerance. In pregnan cy, the enhanced Th2/Th1 ratio seems to be necessary to fetal protection. T aking into account that a Th2-type response means antibody production by B cells, and that these antibodies could induce degradation of the paternal a ntigens, we investigated the quality of the antibodies produced during preg nancy and their regulation. METHOD OF STUDY: Review of previous data. RESULTS: The regulation of protective antibodies by IL-6 in a dose-dependen t fashion is proposed as a hypothesis. CONCLUSION: Cytokines play a central role in the success (or failure) of pr egnancy. However, the quality of the synthesized antibodies is also a regul atory key. The preferential synthesis of asymmetric immunoglobulin G antibo dies during pregnancy could be one of the several pathways that lead to a s uccessful pregnancy.