Antiviral, haemolytic and molluscicidal activities of triterpenoid saponins from Maesa lanceolata: Establishment of structure-activity relationships

Citation
S. Apers et al., Antiviral, haemolytic and molluscicidal activities of triterpenoid saponins from Maesa lanceolata: Establishment of structure-activity relationships, PLANTA MED, 67(6), 2001, pp. 528-532
Citations number
16
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PLANTA MEDICA
ISSN journal
0032-0943 → ACNP
Volume
67
Issue
6
Year of publication
2001
Pages
528 - 532
Database
ISI
SICI code
0032-0943(200108)67:6<528:AHAMAO>2.0.ZU;2-U
Abstract
Ten saponins isolated from the leaves of Maesa lanceolata were tested for t heir antiviral, haemolytic and molluscicidal activities. The influence of t he substitution pattern of these acylated triterpenoid saponins on their bi ological activities was investigated and structure-activity relationships w ere established. Maesasaponin VI2 (3 beta -O-{[alpha -L-rhamnopyranosyl-(1 --> 2)-beta -D-galactopyranosyl-(1 -->3)]-[beta -D-galactopyranosyl-(1 --> 2)]-beta -D-glucopyranuronyl}-21 beta ,22 alpha -diangeloyloxy-13 beta ,28- epoxyolean-16 alpha ,28 alpha -diol), the most potent molluscicidal compoun d (LC50 0.5 ppm), also showed virucidal and haemolytic activity. In general , 21,22-diacylation appeared to be associated with a virucidal (reduction f actor of the viral titer greater than or equal to 10(3) at 50 mug/ml) and h aemolytic activity (HC50 less than or equal to1 mug/ml).