Dynamic scintigraphy with thallium-201 chloride (Tl-201) for the diagnosisof tumors of the head and neck

Citation
T. Sato et al., Dynamic scintigraphy with thallium-201 chloride (Tl-201) for the diagnosisof tumors of the head and neck, ORAL SURG O, 92(2), 2001, pp. 228-235
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Dentistry/Oral Surgery & Medicine
Journal title
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS
ISSN journal
1079-2104 → ACNP
Volume
92
Issue
2
Year of publication
2001
Pages
228 - 235
Database
ISI
SICI code
1079-2104(200108)92:2<228:DSWTC(>2.0.ZU;2-E
Abstract
Objective. The purpose of this study was to differentiate between malignant tumors and benign tumors of the head and neck by means of thallium-201 chl oride scintigraphy. Study design. Thallium-201 chloride (Tl-201) scintigraphy and Ga-67 citrate (Ga-67) scintigraphy were performed in 10 patients with a benign tumor and in 90 patients with a malignant tumor. The blood flow index and the tumor retention index were obtained by means of Tl-201 scintigraphy. The blood fl ow index = the count of tumor/the count of control in the early dynamic sca n from 30 to 120 seconds after injection, and the tumor retention index = ( the count of tumor/the count of control in the delayed dynamic scan 2.5 hou rs after injection)/(the count of tumor/the count of control in the early d ynamic scan from 4 to 5 minutes after injection). Results. The early and delayed scans with Tl-201 demonstrated a very high c orrelation with the blood flow index. The tumor retention index had a tende ncy to increase in malignant tumors, especially in the poorly differentiate d tumors and the severely invasive tumors. Likewise, the tumor retention in dex decreased in benign tumors. These results proved to be statistically si gnificant, and in turn Tl-201 scintigraphy was deemed superior to Ga-67 sci ntigraphy. TI-201 scintigraphy was also useful in detecting small-size tumo rs. Conclusion. The tumor retention index of Tl-201 was useful for the differen tiation of malignant tumors of the head and neck from benign tumors of the same areas.