Grey matter abnormalities in multiple sclerosis: proton magnetic resonancespectroscopic imaging

Citation
R. Sharma et al., Grey matter abnormalities in multiple sclerosis: proton magnetic resonancespectroscopic imaging, MULT SCLER, 7(4), 2001, pp. 221-226
Citations number
18
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
MULTIPLE SCLEROSIS
ISSN journal
1352-4585 → ACNP
Volume
7
Issue
4
Year of publication
2001
Pages
221 - 226
Database
ISI
SICI code
1352-4585(200108)7:4<221:GMAIMS>2.0.ZU;2-B
Abstract
Pathologically defined abnormalities in the cortical gray matter (GM) are w ell described in multiple sclerosis (MS) but are infrequently seen by conve ntional magnetic resonance imaging (MRI). We systematically evaluated 52 re lapsing-remitting MS patients and 20 normal volunteers with high resolution MRI and short echo proton magnetic resonance spectroscopic imaging (MRSI). Individual tissue contributions to the spectroscopic voxels were estimated based on MRI that incorporated both CSF suppression and magnetization tran sfer, or double inversion images in which both CSF and GM were suppressed. Strong resonances in the 0.8 to 1.5 p.p.m. spectral region were observed in 13 MS patients. Image segmentation based on the MRI characteristics of tis sues contributing to the spectroscopic voxels showed that these additional peaks originated mainly from GM. The presence of these additional peaks sug gests that the normal appearance GM on MRI, is biochemically abnormal in a substantial proportion of relapsing-remitting MS patients.