Successful bone marrow transplantation for adult T-cell leukemia from a donor with oligoclonal proliferation of T-cells infected with human T-cell lymphotropic virus

Citation
Y. Kishi et al., Successful bone marrow transplantation for adult T-cell leukemia from a donor with oligoclonal proliferation of T-cells infected with human T-cell lymphotropic virus, LEUK LYMPH, 42(4), 2001, pp. 819-822
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology,"Onconogenesis & Cancer Research
Journal title
LEUKEMIA & LYMPHOMA
ISSN journal
1042-8194 → ACNP
Volume
42
Issue
4
Year of publication
2001
Pages
819 - 822
Database
ISI
SICI code
1042-8194(200108)42:4<819:SBMTFA>2.0.ZU;2-C
Abstract
We describe a patient who underwent successful BMT from her sibling for the treatment of adult T-cell leukemia/lymphoma. Pre-transplant examination of the donor revealed oligoclonal integration of HTLV-1 proviruses within the germ line, and our concern was that clinical sequelae of HLTV-1 infection might become evident in the setting of post-transplant immunosuppression. H owever, the patient has been in complete remission for 14 months after tran splantation, and no clonality of HTLV-1 provirus was detected in the periph eral blood cells using southern blotting analysis. Our experience supports the possibility of transplantation from HTLV-1 positive donors.