Two new triterpenoids, lucidenic acid N(1) and methyl lucidenate F (2), tog
ether with four known compounds, lucidenic acid A, lucidenolactone, luciden
ic acid C, and ganoderic acid E, were isolated from the dried fruiting bodi
es of Ganoderma lucidum. Their struct-es were elucidated by spectral and ch
emical transformation studies. Among them, lucidenic acid N (1), lucidenic
acid A, and ganoderic acid E showed significant cytotoxic activity against
Hep G2, Hep G2,2,15, and P-388 tumor cells.