A compound (1) with the structure proposed for giganticine, an antifeedant
principle isolated from the root bark of Caloropis gigantea, has been succe
ssfully synthesized by two independent methods. Comparison of physical prop
erties and spectroscopic data of 1 with giganticine revealed that they are
different compounds. All available evidence suggests that the proposed stru
cture of giganticine is incorrect.