Microbial transformation of pyrethrosin

Authors
Galal, AM
Citation
Am. Galal, Microbial transformation of pyrethrosin, J NAT PROD, 64(8), 2001, pp. 1098-1099
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
0163-3864 → ACNP
Volume
64
Issue
8
Year of publication
2001
Pages
1098 - 1099
Database
ISI
SICI code
0163-3864(200108)64:8<1098:MTOP>2.0.ZU;2-Q
Abstract
Microbial transformation of the germacranolide pyrethrosin (1) using Rhizop us nigricans NRRL 1477 has resulted in the isolation of 6 alpha -acetoxy-1 beta ,4 alpha -dihydroxy-5,7 alphaH,8 betaH-eudesm-11 beta ,13-dihydro-8,12 -olide (5), a new eudesmanolide-type metabolite, in addition to the previou sly reported eudesmanolides: 2, 3, 4, and 6. The structure elucidation of t hese metabolites was based primarily on 1D and 2D NMR analyses. The isolate d metabolites exhibited cytotoxic, antifungal, and antiprotozoal activities .