Production of aromatic minimal polyketides by the daunorubicin polyketide synthase genes reveals the incompatibility of the heterologous DpsY and JadI cyclases

Authors
Wohlert, SE Wendt-Pienkowski, E Bao, WL Hutchinson, CR
Citation
Se. Wohlert et al., Production of aromatic minimal polyketides by the daunorubicin polyketide synthase genes reveals the incompatibility of the heterologous DpsY and JadI cyclases, J NAT PROD, 64(8), 2001, pp. 1077-1080
Citations number
28
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
0163-3864 → ACNP
Volume
64
Issue
8
Year of publication
2001
Pages
1077 - 1080
Database
ISI
SICI code
0163-3864(200108)64:8<1077:POAMPB>2.0.ZU;2-A
Abstract
Our investigations into whether the biosynthesis of a linearly fused ring s ystem of an aromatic polyketide (jadomycin) could be modified to produce an angularly fused system (daunorubicin) and vice versa showed that introduct ion of the respective cyclases did not have the desired effect. Genes from the daunorubicin pathway produced a novel 21-carbon polyketide.