Se. Wohlert et al., Production of aromatic minimal polyketides by the daunorubicin polyketide synthase genes reveals the incompatibility of the heterologous DpsY and JadI cyclases, J NAT PROD, 64(8), 2001, pp. 1077-1080
Our investigations into whether the biosynthesis of a linearly fused ring s
ystem of an aromatic polyketide (jadomycin) could be modified to produce an
angularly fused system (daunorubicin) and vice versa showed that introduct
ion of the respective cyclases did not have the desired effect. Genes from
the daunorubicin pathway produced a novel 21-carbon polyketide.