New jatrophane diterpenoid esters from Euphorbia turczaninowii

Authors
Citation
Lg. Liu et Rx. Tan, New jatrophane diterpenoid esters from Euphorbia turczaninowii, J NAT PROD, 64(8), 2001, pp. 1064-1068
Citations number
22
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
0163-3864 → ACNP
Volume
64
Issue
8
Year of publication
2001
Pages
1064 - 1068
Database
ISI
SICI code
0163-3864(200108)64:8<1064:NJDEFE>2.0.ZU;2-I
Abstract
Five new (1-5) and one known (6) jatrophane diterpenoid esters were isolate d from the ethanol extract of the whole herb of Euphorbia. turczaninowii. T heir structures were established by extensive spectroscopic methods. The ab solute stereochemistry of 3 beta ,5 alpha ,8 alpha ,15 beta -tetraacetoxy-7 beta -benzoyloxyjatropha-6(17),11E-dien-9,14-dione (1) was confirmed by a single-crystal X-ray analysis coupled with the exciton chirality circular d ichroism. method. Compounds 1-6 were inactive when evaluated both in a mous e ear inflammation assay and for cytotoxicity against the B16 mouse melanom a cell line.