Isolation of new protein phosphatase inhibitors from two cyanobacteria species, Planktothrix spp.

Authors
Sano, T Usui, T Ueda, K Osada, L Kaya, K
Citation
T. Sano et al., Isolation of new protein phosphatase inhibitors from two cyanobacteria species, Planktothrix spp., J NAT PROD, 64(8), 2001, pp. 1052-1055
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
0163-3864 → ACNP
Volume
64
Issue
8
Year of publication
2001
Pages
1052 - 1055
Database
ISI
SICI code
0163-3864(200108)64:8<1052:IONPPI>2.0.ZU;2-M
Abstract
Two new protein phosphatase inhibitors, oscillamide B (1) and C (2), were i solated from the cyanobacteria Planktothrix (Oscillatoria) agardhii and P. rubescens. The structures of the inhibitors were elucidated by analysis of HRFABMS, 1D and 2D NMR spectra, and chemical degradation. These inhibitors are ureido-containing cyclic peptides and inhibited serine/threonine protei n phosphatases PP1 and PP2A. The inhibitory activities were closely related to the Arg and N-Me-Hty residues in the peptides.