Cytotoxic dolabellane diterpenes from the formosan soft coral Clavularia inflata

Citation
Cy. Duh et al., Cytotoxic dolabellane diterpenes from the formosan soft coral Clavularia inflata, J NAT PROD, 64(8), 2001, pp. 1028-1031
Citations number
23
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
0163-3864 → ACNP
Volume
64
Issue
8
Year of publication
2001
Pages
1028 - 1031
Database
ISI
SICI code
0163-3864(200108)64:8<1028:CDDFTF>2.0.ZU;2-Z
Abstract
Six new cytotoxic dolabellane diterpenes, (1R*,12R*)-dolabella-4(16),7,10-t riene-3,13-dione (1), (1R*,7R*,8S*,12R*)-dolabella-4(16),10-diene-7,8-epoxy - 3,13-dione (3), (1R*),10R*,11S*,12R*)-dolabella-4(16),7-diene10.11-epoxy- 3,13-dione (3), (1R*)-dolabella-4(16),7,11(12)-triene-3,13-dione (4), (1R*, 3R*)-3-hydroxydolabella-4(16),7,11(12)-triene-3,13-dione (5), and (1R*,7R*) -7-hydroperoxydolabella-4(16),8(17),11(12)-triene-3,13-dione (6), have been isolated from the Formosan soft coral Clavularia inflata. The structures o f compounds 1-6 were determined by 1D and 2D spectral analysis, and their c ytotoxicity against selected cancer cells was measured in vitro.