New bromoditerpenes from the red alga Sphaerococcus coronopifolius

Citation
S. Etahiri et al., New bromoditerpenes from the red alga Sphaerococcus coronopifolius, J NAT PROD, 64(8), 2001, pp. 1024-1027
Citations number
18
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
0163-3864 → ACNP
Volume
64
Issue
8
Year of publication
2001
Pages
1024 - 1027
Database
ISI
SICI code
0163-3864(200108)64:8<1024:NBFTRA>2.0.ZU;2-7
Abstract
The organic extract of the red alga Sphaerococcus coronopifolius, collected along the Atlantic coast of Morocco, was tested for biological activities and exhibited antibiotic and antimalarial. activities. Two new bromoditerpe nes have been isolated from S. coronopifolius, sphaerolabdadiene-3,14-diol (1) and bromosphaerone (2), along with the known compounds 12S-hydroxybromo sphaerodiol (3) and sphaerococcenol A (4). Bromosphaerone and 12S-hydroxybr omosphaerodiol showed antibacterial activity against the Gram-positive bact erium species Staphylococcus aureus with a minimum inhibitory concentration of 0.104 and 0.146 muM, respectively. Sphaerococcenol A (4) was responsibl e for the antimalarial activity of the extract, against the chloroquine res istant Plasmodium falsciparum FCB1 strains with an IC50 of 1 muM. Their str uctures have been assigned using 1 and 2 D NMR and HRMS.