Dicerandrols, new antibiotic and cytotoxic dimers produced by the fungus Phomopsis longicolla isolated from an endangered mint

Citation
Mm. Wagenaar et J. Clardy, Dicerandrols, new antibiotic and cytotoxic dimers produced by the fungus Phomopsis longicolla isolated from an endangered mint, J NAT PROD, 64(8), 2001, pp. 1006-1009
Citations number
18
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Agricultural Chemistry","Pharmacology & Toxicology
Journal title
JOURNAL OF NATURAL PRODUCTS
ISSN journal
0163-3864 → ACNP
Volume
64
Issue
8
Year of publication
2001
Pages
1006 - 1009
Database
ISI
SICI code
0163-3864(200108)64:8<1006:DNAACD>2.0.ZU;2-G
Abstract
Bioassay-guided fractionation of the organic extract from a culture of Phom opsis longicolla, an endophytic fungus of the endangered mint Dicerandra fr utescens, led to the isolation of dicerandrols A, B, and C. Extensive NMR a nd HRFABMS experiments were used to identify these new yellow antibiotic an d cytotoxic compounds as 2,2 ' -dimeric tetrahydroxanthones.