A four-step synthesis of the PARP inhibitor 2-(4-trifluoromethylphenyl)benz
imidazole-4-carboxamide (1, NU1077) is presented. Condensation of 2,3-diami
notoluene and 4-trifluoromethylbenzaldehyde afforded 4-methyl-2-(4-trifluor
omethylphenyl)benzimidazole. Oxidation of the methyl group with potassium p
ermanganate in warm t-butanol afforded the carboxylic acid that was convert
ed to the corresponding carboxamide via the acid chloride.