M. Petroliagi et O. Igglessi-markopoulou, Synthesis and NMR spectroscopic studies of optically active derivatives ofgamma-aminobutenoic acids and 2-amino-pyrrolin-4-ones, J HETERO CH, 38(4), 2001, pp. 917-922
An efficient method for the preparation of optically active derivatives of
gamma -amino-butenoic acids and their cyclic derivatives, 2-amino-pyrrolin-
4-ones, from alpha -amino acids is described. Partial racemization accompan
ies the formation of initial unsaturated gamma -amino- beta -hydroxy esters
5-8, as determined by chiral HPLC.