Synthetic approaches to 4,8-dimethyl-5 '(N-pyridiniummethyl)-4 ',5 '-dihydropsoralens and 4,8-dimethyl-5 '-(N-aminomethyl)-4 ',5 '-dihydropsoralens

Citation
Ms. Whittemore et al., Synthetic approaches to 4,8-dimethyl-5 '(N-pyridiniummethyl)-4 ',5 '-dihydropsoralens and 4,8-dimethyl-5 '-(N-aminomethyl)-4 ',5 '-dihydropsoralens, J HETERO CH, 38(4), 2001, pp. 909-916
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
JOURNAL OF HETEROCYCLIC CHEMISTRY
ISSN journal
0022-152X → ACNP
Volume
38
Issue
4
Year of publication
2001
Pages
909 - 916
Database
ISI
SICI code
0022-152X(200107/08)38:4<909:SAT4''>2.0.ZU;2-Q
Abstract
New synthetic approaches to 4,8-dimethyl-5'-(N-pyridiniummethyl)-4',5'-dihy dropsoralens and 4,8-dimethyl-5'-(N-aminomethyl)-4',5'-dihydropsoralens are described. The 5'-halomethyl-4',5'-dihydropsoralen precursors are formed b y electrophilic ring closures of 4,8-dimethyl-6-allyl-7-hydroxycoumarin. Th e ring-closure reactions may also be applied to the synthesis of 5'-halomet hyl-4-methyl-4',5'-dihydroangelicins. The compounds are potential therapeut ic agents for improved psoralen ultraviolet A radiation treatment.