A few spices, which are commonly employed to improve digestion in tradition
al systems of medicine were examined for their possible influence on digest
ive enzymes of pancreas and small intestine in experimental rats. In one se
t of animals, the spices-ajowan, fennel, coriander, onion, garlic and mint
were given through the diet for 8 weeks. In another experiment, the same sp
ices were administered orally as an appropriate single dose to animals. Pan
creatic trypsin was significantly stimulated by all the dietary spices exam
ined except mint, while chymotrypsin was stimulated by coriander and onion.
These two spices also had a significant stimulating influence on intestina
l disaccharidases and alkaline phosphatase. Most of the spices tested in th
is study showed significant enhancing effect on intestinal enzymes, particu
larly lipase and amylase, when given as a single oral dose, while similar b
eneficial effects were not observed on pancreatic enzymes. Among the spices
examined, onion produced a pronounced stimulation of a majority of digesti
ve enzymes of pancreas and small intestine. The positive influences on the
pancreatic and intestinal digestive enzymes exerted by spices could contrib
ute to their well recognised digestive stimulant action.