Study Objective: To investigate whether oral omeprazole 20 mg decreases the
risk of aspiration pneumonia in Patients with gastric tube reconstruction.
Design: Consecutive study.
Setting: Operation room of cancer center.
Patients: Thirteen patients with gastric tube reconstruction for esophageal
Interventions: Oral omeprazole 20 mg was given the night before surgery. A
rapid-sequence induction with cricoid pressure was employed for induction o
f anesthesia. After tracheal intubation, a nasogastric catheter was inserte
d into the gastric tube and the contents were aspirated.
Measurements and Main Results: The PH and volume of the gastric contents we
re measured. The PH and volume of the gastric tube contents were 4.5 +/- 1.
6 (range from 2.5 to 7.0) and 9.5 +/- 10.2 mL (range from 0 to 30 mL), resp
ectively. Food residue was recognized in nine patients. There was no patien
t with a PH below 2.5 and a volume of 25 mL or greater.
Conclusions: Omeprazole 20 mg decreased the acidify and volume of the gastr
ic tube contents and reduced the risk of aspiration pneumonia in patients w
ith a gastric tube in place. (C) 2001 by Elsevier Science Inc.