Mechanical fluid flow enhances High-Affinity-IgE-Receptor-Mediated secretion by mast cells adherent to fibronectin

Citation
Y. Mita et al., Mechanical fluid flow enhances High-Affinity-IgE-Receptor-Mediated secretion by mast cells adherent to fibronectin, J ASTHMA, 38(5), 2001, pp. 435-441
Citations number
40
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Respiratory Systems
Journal title
JOURNAL OF ASTHMA
ISSN journal
0277-0903 → ACNP
Volume
38
Issue
5
Year of publication
2001
Pages
435 - 441
Database
ISI
SICI code
0277-0903(2001)38:5<435:MFFEHS>2.0.ZU;2-8
Abstract
We demonstrated the effect of interaction between mechanical fluid flow and the extracellular matrix on high-affinity-IgE-receptor (Fc epsilon RI)-med iated secretion by mast cells (cell line MC/9). Mechanical fluid flow did n ot affect secretion by the cells in the absence of exogenou agonists. Mecha nical fluid flow did not affect secretion by cells adherent to fibronectin in the absence of exogenous agonists, but it did enhance Fc epsilon RI-medi ated secretion by cells adherent to fibronectin. These finding indicate tha t fluid-flow-induced enhancement of secretion by mast cells requires both e xogenous agonists and interaction between integrins and the extracellular m atrix. The present study is the first to demonstrate that mechanical fluid flow enhances Fc epsilon RI-mediated secretion by a mast cell line adherent to fibronectin.