Aflatoxins and fumonisins in corn from the high-incidence area for human hepatocellular carcinoma in Guangxi, China

Citation
Fq. Li et al., Aflatoxins and fumonisins in corn from the high-incidence area for human hepatocellular carcinoma in Guangxi, China, J AGR FOOD, 49(8), 2001, pp. 4122-4126
Citations number
27
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Agricultural Chemistry","Chemistry & Analysis
Journal title
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN journal
0021-8561 → ACNP
Volume
49
Issue
8
Year of publication
2001
Pages
4122 - 4126
Database
ISI
SICI code
0021-8561(200108)49:8<4122:AAFICF>2.0.ZU;2-Q
Abstract
A comparative study on the natural occurrence of aflatoxins and Fusarium to xins was conducted with corn samples from high- and low-incidence areas for human primary hepatocellular carcinoma (PHC) in Guangxi, China. In samples from the high-risk area, aflatoxin B-1 was the predominant toxin detected in terms of quantity and frequency, with its concentration ranging between 9 and 2496 mug/kg and an 85% incidence of contamination. Among the samples, 13 (76%) exceeded the Chinese regulation of 20 mug/kg for aflatoxin B-1 in corn and corn-based products intended for human consumption. Significant d ifferences in aflatoxin B-1, B-2, and G(1) and total aflatoxin concentratio ns in corn between the areas were found (P < 0.05). The average daily intak e of aflatoxin B-1 from corn in the high-risk area was 184.1 mug, and the p robable daily intake is estimated to be 3.68 mug/kg of body weight/day, 3.2 0 times the TD50 in rats. Corn samples from both areas were simultaneously contaminated with fumonisins B-1, B-2, and B-3. Aflatoxin B-1 may play an i mportant role in the development of PHC in Guangxi.