Mouse erythroblast formation is inhibited by anemia-inducing substance from the plasma of a patient with a malignant neoplasm

Citation
K. Honda et al., Mouse erythroblast formation is inhibited by anemia-inducing substance from the plasma of a patient with a malignant neoplasm, INT J MOL M, 8(3), 2001, pp. 257-260
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medical Research General Topics
Journal title
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
ISSN journal
1107-3756 → ACNP
Volume
8
Issue
3
Year of publication
2001
Pages
257 - 260
Database
ISI
SICI code
1107-3756(200109)8:3<257:MEFIIB>2.0.ZU;2-X
Abstract
An anemia-inducing substance (AIS) was found as a protein, with a molecular weight of 50,000 on SDS electrophoresis gel, that decreased the osmotic re sistance of erythrocytes. In this study, the plasma fraction containing AIS is shown to inhibit mouse erythroblast formation in vitro. The addition of the plasma fraction from a patient with an advanced malignant neoplasm to a liquid culture of mouse bone marrow cells with erythropoietin results in low numbers of erythroblast formation and low cellular yields of alpha- and beta -globin mRNAs. These inhibitions were not observed after immunoadsorp tion of the plasma fraction with an antiserum against AIS.