Repetitious appearance and disappearance of different kinds of clonal cytogenetic abnormalities after allogeneic bone marrow transplantation

Citation
Yw. Lin et al., Repetitious appearance and disappearance of different kinds of clonal cytogenetic abnormalities after allogeneic bone marrow transplantation, INT J HEMAT, 74(1), 2001, pp. 86-89
Citations number
16
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology
Journal title
INTERNATIONAL JOURNAL OF HEMATOLOGY
ISSN journal
0925-5710 → ACNP
Volume
74
Issue
1
Year of publication
2001
Pages
86 - 89
Database
ISI
SICI code
0925-5710(200107)74:1<86:RAADOD>2.0.ZU;2-3
Abstract
We report a childhood case that showed the repeated appearance and disappea rance of various kinds of cytogenetic abnormalities (CA) for 5.5 years afte r allogeneic bone marrow transplantation (BMT). The patient underwent allog eneic BMT from an HLA-matched unrelated donor during the second complete re mission of acute lymphoblastic leukemia. The conditioning regimen for BMT c onsisted of etoposide, cyclophosphamide. anti-human thymocyte immunoglobuli n, and total body irradiation. There were no leukemic relapses or secondary acute myeloid leukemia/myelodysplastic syndrome (AML/MDS) since the BMT. T he CA occurred from residual recipient cells, which were damaged by chemoth erapy or radiation prior to BMT. Although previous studies about post-BMT C A had reported the continuous emergence of identical clones, the present ca se showed the appearance of one different type of clone after another. Alth ough the appearance of different types of CA may mean that these clones did not obtain any growth advantages, it may be a sign of genomic instability, which is probably a risk factor for the development of secondary AML/MDS. (C) 2001 The Japanese Society of Hematology.