Toll-like receptor 2 and 4 surface expressions on human monocytes are modulated by interferon-gamma and macrophage colony-stimulating factor

Citation
Y. Mita et al., Toll-like receptor 2 and 4 surface expressions on human monocytes are modulated by interferon-gamma and macrophage colony-stimulating factor, IMMUNOL LET, 78(2), 2001, pp. 97-101
Citations number
26
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology
Journal title
IMMUNOLOGY LETTERS
ISSN journal
0165-2478 → ACNP
Volume
78
Issue
2
Year of publication
2001
Pages
97 - 101
Database
ISI
SICI code
0165-2478(20010903)78:2<97:TR2A4S>2.0.ZU;2-7
Abstract
Human Toll-like receptor 2 (TLR2) and TLR4 are recently identified receptor s. TLR4 was shown to be the main protein involved in recognizing Gram-negat ive bacteria, whereas TLR2 is apparently the key factor in responses to oth er types of microbial pathogens. We examined regulations of TLR2 and TLR4 s urface expressions in human peripheral blood monocytes by interferon-gamma (IFN-gamma) and macrophage colony-stimulating factor (M-CSF). IFN-gamma up- regulated both TLR2 and TLR4, but enhanced the surface expression, on human peripheral blood monocytes of TLR4 more than that of TLR2. On the other ha nd, M-CSF up-regulated both TLR2 and TLR4 surface expression on human perip heral blood monocytes, with no change in the ratio of TLR2/TLR4 surface exp ression. These results indicate that IFN-gamma enhances receptors involved in the response to Gram-negative bacteria more than those involved in respo nses to other types of microbial pathogens, whereas M-CSF enhances the rece ptor response to Gram-negative bacteria in the same manner as to other type s of microbial pathogens. (C) 2001 Elsevier Science BN. All rights reserved .