Superoxide dismutase mutations of familial amyotrophic lateral sclerosis and the oxidative inactivation of calcineurin

Citation
H. Volkel et al., Superoxide dismutase mutations of familial amyotrophic lateral sclerosis and the oxidative inactivation of calcineurin, FEBS LETTER, 503(2-3), 2001, pp. 201-205
Citations number
24
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biochemistry & Biophysics
Journal title
FEBS LETTERS
ISSN journal
0014-5793 → ACNP
Volume
503
Issue
2-3
Year of publication
2001
Pages
201 - 205
Database
ISI
SICI code
0014-5793(20010817)503:2-3<201:SDMOFA>2.0.ZU;2-V
Abstract
Approximately 10% of all familial cases of amyotrophic lateral sclerosis (f ALS) are linked to mutations in the SOD1 gene, which encodes the copper/zin c superoxide dismutase (CuZnSOD). Recently, wild-type CuZnSOD was shown to protect calcineurin, a calcium/calmodulin-regulated phosphoprotein phosphat ase, from inactivation by reactive oxygen species. We asked whether the pro tective effect of CuZnSOD on calcineurin is affected by mutations associate d with fALS. For this, we monitored calcineurin activity in the presence of mutant and wild-type SOD. We found that the degree of protection against i nactivation of calcineurin by different SOD mutants correlates with the sev erity of the phenotype associated with the different mutations, suggesting a potential role for calcineurin-SOD1 interaction in the etiology of fALS. (C) 2001 Federation of European Biochemical Societies. Published by Elsevie r Science B.V. All rights reserved.