Treatment of primary, recurrent or inadequately resected high-risk soft-tissue sarcomas (STS) of adults: results of a phase II pilot study (RHT-95) of neoadjuvant chemotherapy combined with regional hyperthermia

Citation
Cm. Wendtner et al., Treatment of primary, recurrent or inadequately resected high-risk soft-tissue sarcomas (STS) of adults: results of a phase II pilot study (RHT-95) of neoadjuvant chemotherapy combined with regional hyperthermia, EUR J CANC, 37(13), 2001, pp. 1609-1616
Citations number
30
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
EUROPEAN JOURNAL OF CANCER
ISSN journal
0959-8049 → ACNP
Volume
37
Issue
13
Year of publication
2001
Pages
1609 - 1616
Database
ISI
SICI code
0959-8049(200109)37:13<1609:TOPROI>2.0.ZU;2-5
Abstract
The efficacy of thermochemotherapy in adult patients with primary, recurren t or inadequately resected non-metastatic high-risk soft-tissue sarcomas (S TS) was assessed. 54 patients were prospectively treated with four cycles o f etoposide, ifosfamide and doxorubicin (EIA) combined with regional hypert hermia (RHT) followed by surgery, another four cycles of EIA without RHT an d external beam radiation. The objective response rate was 16% and at a med ian follow-up time of 57 months, the 4-year estimated rates of local failur e-free survival (LFFS), distant metastasis-free survival (DMFS), event-free survival (EFS) and overall survival (OS) were 59% (95% confidence interval (CI) 45-73%), 59% (95% CI 44-73%), 26% (95% CI 14-38%) and 40% (95% CI 27- 53%) respectively. OS was in favour of patients responding to neoadjuvant t reatment (P=0.073). In comparison to a preceding phase II study including p re- and postsurgical thermochemotherapy (RHT-91), at a 4-year follow-up the RHT-95 study cohort showed an inferior LFFS rate (P=0.027), but this did n ot affect DMFS (P=0.558) or OS (P=0.126). Hence, postsurgical thermochemoth erapy seems critical for local tumour control without affecting survival. ( C) 2001 Elsevier Service Ltd. All rights reserved.