Recombinase activating gene enzymes of lymphocytes

Citation
Ld. Notarangelo et al., Recombinase activating gene enzymes of lymphocytes, CURR OPIN H, 8(1), 2001, pp. 41-46
Citations number
69
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Hematology
Journal title
CURRENT OPINION IN HEMATOLOGY
ISSN journal
1065-6251 → ACNP
Volume
8
Issue
1
Year of publication
2001
Pages
41 - 46
Database
ISI
SICI code
1065-6251(200101)8:1<41:RAGEOL>2.0.ZU;2-C
Abstract
Expression of T-cell receptor and surface immunoglobulins on T and B lympho cytes, respectively, is strictly dependent on the variable, (diversity) joi ning exon (V(D)J) recombination process, which is initiated by the lymphoid -specific recombinase activating gene proteins 1 and 2 (RAG1 and RAG2). Rec ent advances have highlighted the functional organization of the RAG1 and R AG2 proteins and have provided important information on the regulation of R AG gene expression. Depending on the severity of their effects on the V(D)J recombination process, mutations of the RAG genes account for a spectrum o f combined immune deficiencies in humans. (C) 2001 Lippincott Williams & Wi lkins, Inc.