The neurotrophic factors in non-neuronal tissues

Authors
Citation
H. Sariola, The neurotrophic factors in non-neuronal tissues, CELL MOL L, 58(8), 2001, pp. 1061-1066
Citations number
64
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
CELLULAR AND MOLECULAR LIFE SCIENCES
ISSN journal
1420-682X → ACNP
Volume
58
Issue
8
Year of publication
2001
Pages
1061 - 1066
Database
ISI
SICI code
1420-682X(200107)58:8<1061:TNFINT>2.0.ZU;2-Y
Abstract
Although neurotrophic factors are defined as molecules that maintain neuron al cells, they possess a range of functions outside the nervous system. For example, glial cell line-derived neurotrophic factor is essential for uret eric branching in kidney morphogenesis and for regulating the fate of stem cells during spermatogenesis. Leukemia inhibitory factor, a member of the i nterleukin-6 (IL-6) ciliary neurotrophic factor family, inhibits differenti ation of embryonic stem cells, induces tubulogenesis in the embryonic kidne y, and regulates sperm differentiation. Other IL-6 family members are impor tant in cardiac differentiation and they have pleiotropic functions in the hematopoietic and immune systems. Although neurotrophin receptors have been found on a number of non-neuronal tissues, they represent mostly truncated receptor isoforms that are incapable of signal transduction and may have s cavenger or dominant negative functions. However, several examples can be p resented of essential non-neuronal functions played by neurotrophins in e.g ., cardiac, hair follicle, and vascular differentiation, and the maintenanc e of immune cells.