Neurotrophins and neuronal differentiation in the central nervous system

Authors
Citation
Ak. Mcallister, Neurotrophins and neuronal differentiation in the central nervous system, CELL MOL L, 58(8), 2001, pp. 1054-1060
Citations number
72
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
CELLULAR AND MOLECULAR LIFE SCIENCES
ISSN journal
1420-682X → ACNP
Volume
58
Issue
8
Year of publication
2001
Pages
1054 - 1060
Database
ISI
SICI code
1420-682X(200107)58:8<1054:NANDIT>2.0.ZU;2-H
Abstract
The central nervous system requires the proper formation of exquisitely pre cise circuits to function properly. These neuronal circuits are assembled d uring development by the formation of synaptic connections between hundreds of thousands of differentiating neurons. For these circuits to form correc tly, neurons must elaborate precisely patterned axonal and dendritic arbors . Although the cellular and molecular mechanisms that guide neuronal differ entiation and formation of connections remain mostly unknown, the neurotrop hins have emerged recently as attractive candidates for regulating neuronal differentiation in the developing brain. The experiments reviewed here pro vide strong support for a bifunctional role for the neurotrophins in axonal and dendritic growth and are consistent with the exciting possibility that the neurotrophins might mediate activity-dependent synaptic plasticity.