Neurotrophin signalling pathways regulating neuronal apoptosis

Citation
Fd. Miller et Dr. Kaplan, Neurotrophin signalling pathways regulating neuronal apoptosis, CELL MOL L, 58(8), 2001, pp. 1045-1053
Citations number
95
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
CELLULAR AND MOLECULAR LIFE SCIENCES
ISSN journal
1420-682X → ACNP
Volume
58
Issue
8
Year of publication
2001
Pages
1045 - 1053
Database
ISI
SICI code
1420-682X(200107)58:8<1045:NSPRNA>2.0.ZU;2-A
Abstract
Recent evidence indicates that naturally occurring neuronal death in mammal s is regulated by the interplay between receptor-mediated prosurvival and p roapoptotic signals. The neurotrophins, a family of growth factors best kno wn for their positive effects on neuronal biology, have now been shown to m ediate both positive and negative survival signals, by signalling through t he Trk and p75 neurotrophin receptors, respectively. The mechanisms whereby these two neurotrophin receptors interact to determine neuronal survival h ave been difficult to decipher, largely because both can signal independent ly or coincidentally, depending upon the cell or developmental context. Non etheless, the past several years have seen significant advances in our unde rstanding of this receptor signalling system. In this review, we focus on t he proapoptotic actions of the p75 neurotrophin receptor (p75(NTR)), and on the interplay between Trk and p75(NTR) that determines neuronal survival.