Receptor binding, internalization, and retrograde transport of neurotrophic factors

Citation
Ke. Neet et Rb. Campenot, Receptor binding, internalization, and retrograde transport of neurotrophic factors, CELL MOL L, 58(8), 2001, pp. 1021-1035
Citations number
150
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
CELLULAR AND MOLECULAR LIFE SCIENCES
ISSN journal
1420-682X → ACNP
Volume
58
Issue
8
Year of publication
2001
Pages
1021 - 1035
Database
ISI
SICI code
1420-682X(200107)58:8<1021:RBIART>2.0.ZU;2-R
Abstract
This review deals with the receptor interactions of neurotrophic factors, f ocusing on the neurotrophins of the nerve growth factor (NGF) family, the g lial cell derived neurotrophic factor (GDNF) family, and the ciliary neurot rophic factor (CNTF) family. The finding that two proteins, p75(NTR) and Tr k, act as receptors for NGF in neurons generated the discovery of other neu rotrophic factors/receptor families and has enhanced our understanding of t he development, survival, regeneration, and degeneration of the nervous sys tem. The kinetics of binding, the structure of the ligand-receptor complex, and the mechanism of retrograde transport of the neurotrophins are discuss ed in detail and compared to information available on the GDNF and CNTF fam ilies. Each neurotrophic factor family, i.e., NGF, GDNF, and CNTF, has a se t of receptors with specificity for individual members of the family and a common receptor without member specificity that, in some families, generate s the cellular signal and retrograde transport.