Neurotrophic factor structures reveal clues to evolution, binding, specificity, and receptor activation

Authors
Citation
Mj. Butte, Neurotrophic factor structures reveal clues to evolution, binding, specificity, and receptor activation, CELL MOL L, 58(8), 2001, pp. 1003-1013
Citations number
103
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Cell & Developmental Biology
Journal title
CELLULAR AND MOLECULAR LIFE SCIENCES
ISSN journal
1420-682X → ACNP
Volume
58
Issue
8
Year of publication
2001
Pages
1003 - 1013
Database
ISI
SICI code
1420-682X(200107)58:8<1003:NFSRCT>2.0.ZU;2-E
Abstract
The neutrophin family, the glial-derived neurotrophic factor family, and th e ciliary neurotrophic factor are the best described growth factors specifi c for developing neurons and neutral crest cells. As might be expected for regulatory molecules of the complex central and peripheral nervous system, these factors show considerable receptor specificity and cross-talk. Thanks to a decade of intense research by numerous laboratories, the structures o f many of these factors are now available. This review discusses the struct ural bases of receptor binding, specificity, and activation in each of thes e systems. Using structure-based sequence alignments, the evolutionary impl ications of these molecules and their receptors are discussed, followed by suggestions for further directions for research on the structure and functi on of these neurotrophic factors.