Association of maspin expression with the malignancy grade and tumor vascularization in breast cancer tissues

Citation
T. Hojo et al., Association of maspin expression with the malignancy grade and tumor vascularization in breast cancer tissues, CANCER LETT, 171(1), 2001, pp. 103-110
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER LETTERS
ISSN journal
0304-3835 → ACNP
Volume
171
Issue
1
Year of publication
2001
Pages
103 - 110
Database
ISI
SICI code
0304-3835(20010928)171:1<103:AOMEWT>2.0.ZU;2-P
Abstract
Maspin belongs to a tumor suppressing protein which is usually expressed hi ghly in myoepithelial cells, and is significantly downregulated in breast c ancer cells. We focused on identifying the correlation between maspin expre ssion and the clinicopathological features of human breast cancer tissues u sing immunohistochemistry. There was a significant correlation in that masp in-positive tumor specimens showed a low pathological grade of malignancy, such as a lower infiltration of the tumor into the surrounding tissue and a downregulation of c-erbB2 expression. Moreover, maspin-positive cases show ed a significant decrease in tumor vessels positively stained with anti-fac tor VIII-related antigen antibody. These results suggest that maspin produc tion in myoepithelial cells could downregulate the malignant phenotype of b reast cancer. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.