Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine
A. Hagiwara et al., Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine, CANCER LETT, 171(1), 2001, pp. 17-25
The potential of purple corn color (PCC), a natural anthocyanin, to modify
colorectal carcinogenesis was investigated in male F344/DuCrj rats, initial
ly treated with 1,2-dimethylhydrazine (DMH), receiving 2-amino-1-methyl-6-p
henylimidazo[4,5-b]pyridine (PhIP) in the diet. After DMH initiation, PCC w
as given at a dietary level of 5.0% in combination with 0.02% PhIP until we
ek 36. No PCC-treatment-related changes in clinical signs, body weight and
food consumption were found. Incidences and multiplicities of colorectal ad
enomas and carcinomas in rats initiated with DMH were clearly increased by
PhIP. In contrast, lesion development was suppressed by PCC administration.
Furthermore, in the non-DMH initiation groups, induction of aberrant crypt
foci by PhIP tended to be decreased by the PCC supplementation. The result
s thus demonstrate that while PhIP clearly exerts promoting effects on DMH-
induced colorectal carcinogenesis, these can be reduced by 5.0% PCC in the
diet, under the present experimental conditions. (C) 2001 Elsevier Science
Ireland Ltd. All rights reserved.