Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine

Citation
A. Hagiwara et al., Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine, CANCER LETT, 171(1), 2001, pp. 17-25
Citations number
33
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
CANCER LETTERS
ISSN journal
0304-3835 → ACNP
Volume
171
Issue
1
Year of publication
2001
Pages
17 - 25
Database
ISI
SICI code
0304-3835(20010928)171:1<17:PIBANA>2.0.ZU;2-B
Abstract
The potential of purple corn color (PCC), a natural anthocyanin, to modify colorectal carcinogenesis was investigated in male F344/DuCrj rats, initial ly treated with 1,2-dimethylhydrazine (DMH), receiving 2-amino-1-methyl-6-p henylimidazo[4,5-b]pyridine (PhIP) in the diet. After DMH initiation, PCC w as given at a dietary level of 5.0% in combination with 0.02% PhIP until we ek 36. No PCC-treatment-related changes in clinical signs, body weight and food consumption were found. Incidences and multiplicities of colorectal ad enomas and carcinomas in rats initiated with DMH were clearly increased by PhIP. In contrast, lesion development was suppressed by PCC administration. Furthermore, in the non-DMH initiation groups, induction of aberrant crypt foci by PhIP tended to be decreased by the PCC supplementation. The result s thus demonstrate that while PhIP clearly exerts promoting effects on DMH- induced colorectal carcinogenesis, these can be reduced by 5.0% PCC in the diet, under the present experimental conditions. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.