Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine

Hagiwara, A Miyashita, K Nakanishi, T Sano, M Tamano, S Kadota, T Koda, T Nakamura, M Imaida, K Ito, N Shirai, T

A. Hagiwara et al., Pronounced inhibition by a natural anthocyanin, purple corn color, of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)associated colorectal carcinogenesis in male F344 rats pretreated with 1,2-dimethylhydrazine, CANCER LETT, 171(1), 2001, pp. 17-25

33

INGLESE

Article

Onconogenesis & Cancer Research

CANCER LETTERS

0304-3835 → ACNP

171

1

2001

17 - 25

ISI

0304-3835(20010928)171:1<17:PIBANA>2.0.ZU;2-B

The potential of purple corn color (PCC), a natural anthocyanin, to modify colorectal carcinogenesis was investigated in male F344/DuCrj rats, initial ly treated with 1,2-dimethylhydrazine (DMH), receiving 2-amino-1-methyl-6-p henylimidazo[4,5-b]pyridine (PhIP) in the diet. After DMH initiation, PCC w as given at a dietary level of 5.0% in combination with 0.02% PhIP until we ek 36. No PCC-treatment-related changes in clinical signs, body weight and food consumption were found. Incidences and multiplicities of colorectal ad enomas and carcinomas in rats initiated with DMH were clearly increased by PhIP. In contrast, lesion development was suppressed by PCC administration. Furthermore, in the non-DMH initiation groups, induction of aberrant crypt foci by PhIP tended to be decreased by the PCC supplementation. The result s thus demonstrate that while PhIP clearly exerts promoting effects on DMH- induced colorectal carcinogenesis, these can be reduced by 5.0% PCC in the diet, under the present experimental conditions. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.