Renal cortical retention on delayed CT and nephropathy following transcatheter arterial chemoembolisation

Citation
H. Yamazaki et al., Renal cortical retention on delayed CT and nephropathy following transcatheter arterial chemoembolisation, BR J RADIOL, 74(884), 2001, pp. 695-700
Citations number
18
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Medical Research Diagnosis & Treatment
Journal title
BRITISH JOURNAL OF RADIOLOGY
ISSN journal
0007-1285 → ACNP
Volume
74
Issue
884
Year of publication
2001
Pages
695 - 700
Database
ISI
SICI code
Abstract
The aim of this study was to examine the relationship between renal cortica l retention on delayed CT and contrast medium-associated and/or transarteri al chemoembolisation (TACE)-associated nephropathy following TACE. The auth ors reviewed the findings on 180 treatments in 121 patients with normal ser um creatinine levels who underwent TACE for liver tumours. Nephropathy was defined as an increase in the creatinine level of greater than 0.5 mg dl(-1 ) (44 mu mol l(-1)) and greater than 25% on days 1, 3, 7 or 14 post TACE. R enal cortical retention was recognized when CT values for the renal cortex showed either mild renal cortical retention (CT value > 50) or severe renal cortical retention (CT value > 100). There was evidence of renal cortical retention in 81 (45 h) cases and of nephropathy in 11 (6 %) cases. Only 2% of patients without renal cortical retention showed nephropathy, whereas 11 % of those with renal cortical retention showed nephropathy (p=0.02). Stepw ise selection using a multivariate logistic regression model showed renal c ortical retention and gender to be significant factors for nephropathy foll owing TACE. In conclusion, renal cortical retention is a useful predicator for nephropathy following TACE. Delayed CT could be used not only for asses sment of lipiodol retention but also for predicting nephropathy.