Patients with follicular lymphoma (FL) usually present with advanced diseas
e, with lymph nodes and bone marrow involvement. Extranodal infiltration is
infrequent. In FL isolated cutaneous relapse is a very rare event that, to
the best of our knowledge, has not been previously reported. We report on
a 55-year-old woman with FL who presented with an isolated skin relapse 5 y
ears after the diagnosis. The patient, who had relapsed after three lines o
f chemotherapy, was treated with the chimeric anti-CD20 antibody, rituximab
, achieving a complete response, which has now persisted for more than 24 m
onths.