Synthesis of a library of N-p-hydroxybenzoyl thioureas using a poly(ethylene glycol) support

Citation
Zx. Chen et al., Synthesis of a library of N-p-hydroxybenzoyl thioureas using a poly(ethylene glycol) support, SYNTHESIS-S, (10), 2001, pp. 1483-1486
Citations number
16
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
SYNTHESIS-STUTTGART
ISSN journal
0039-7881 → ACNP
Issue
10
Year of publication
2001
Pages
1483 - 1486
Database
ISI
SICI code
0039-7881(200108):10<1483:SOALON>2.0.ZU;2-J
Abstract
A library of N-p-hydroxybenzoyl thioureas has been synthesized using poly(e thylene glycol) (PEG) as soluble polymer support. PEG and para-hydroxybenzo ic acid were linked by oxalyl chloride to give II. Compound II was acylated by thionyl chloride, followed by esterification with ammonium rhodanate to give IV in which PEG itself also acted as phase-transfer catalyst. Compoun d IV reacted with R1R2NH to yield V. Hydrolysis of V gave VI. This syntheti c method is simple and mild, and the yields a-re moderate to high.