Molecular epidemiology of preterm delivery: methodology and challenges

Citation
Xb. Wang et al., Molecular epidemiology of preterm delivery: methodology and challenges, PAED PERIN, 15, 2001, pp. 63-77
Citations number
156
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Pediatrics
Journal title
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
ISSN journal
0269-5022 → ACNP
Volume
15
Year of publication
2001
Supplement
2
Pages
63 - 77
Database
ISI
SICI code
0269-5022(200107)15:<63:MEOPDM>2.0.ZU;2-0
Abstract
Preterm delivery (PTD) appears to be a complex trait determined by both gen etic and environmental factors. Few studies have examined genetic influence on PTD. The overall goal of our study is to examine major candidate genes of PTD and to test gene-environment interactions. Our study includes 500 pr eterm trios, including 500 preterm babies and their parents and 500 materna l age-matched term controls. We will perform the transmission/disequilibriu m test (TDT) on candidate genes thought to be important in each of the four biological pathways of PTD: (1) decidual chorioamionotic inflammation: int erleukin 1 (IL-1), IL-6, and tumour necrosis factor (TNF); (2) maternal and fetal stress: corticotropin-releasing hormone (CRH); (3) uteroplacental va scular lesions: methylenetereahydrofolate reductase (MTHFR); and (4) suscep tibility to environmental toxins: GSTM1, GSTT1, CYP1A1, CYP2D6, CYP2E1, NAT 2, NQO1, ALDH2, and EPHX. We will also perform standard case-control analys es on the 500 preterm cases and 500 term controls to examine gene environme nt interactions. The major environmental, nutritional and social factors as well as clinical variables known or suspected to be associated with PTD wi ll be used to test for gene-environment interactions. This study integrates epidemiological and clinical data as well as genetic markers along major p athogenic pathways of PTD. The findings from this study should improve our understanding of genetic influences on PTD and gene-environment interaction s.