Is peptic ulcer a common cause of upper gastrointestinal symptoms?

Citation
E. Roma et al., Is peptic ulcer a common cause of upper gastrointestinal symptoms?, EUR J PED, 160(8), 2001, pp. 497-500
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pediatrics,"Medical Research General Topics
Journal title
EUROPEAN JOURNAL OF PEDIATRICS
ISSN journal
0340-6199 → ACNP
Volume
160
Issue
8
Year of publication
2001
Pages
497 - 500
Database
ISI
SICI code
0340-6199(200108)160:8<497:IPUACC>2.0.ZU;2-M
Abstract
The aim of the study was to investigate retrospectively a cohort of childre n with peptic ulcer disease during a period that covers the recent changes in diagnosis and management of the disease. Over a period of 9 years, 2550 children underwent upper gastrointestinal endoscopy for various reasons. Al l children, in whom a diagnosis of primary peptic ulcer was established, we re included in the study. Previous and current medical history, family hist ory, endoscopic and histological outcome were evaluated and the children we re regularly followed-up on an out-patient basis. Primary peptic ulcer was diagnosed in 52 (10 gastric and 42 duodenal, 2%) out of 2550 children. The median age of children with gastric ulcer was 6.5 years, whereas of those w ith duodenal ulcer was 10.5 years (P = 0.04). With regard to clinical sympt oms no significant difference was found between children with and without u lcer. The prevalence of Helicobacter pylori infection was significantly hig her in children with duodenal ulcer (62%) compared to those with gastric ul cer (20%; P < 0.001). At first follow-up visit, I month after the end of tr eatment, 19 symptomatic children underwent a repeat endoscopy, which showed ulcer healing in 95% and failure in H. pylori eradication in 27%. During t he long-term follow-up (median 3.5 years), six children became symptomatic. Two of them had duodenal ulcer associated with positive H. pylori. Conclusion Peptic ulcer disease is an uncommon disorder in childhood with n on specific clinical features; it seems that efficient treatment and succes sful Helicobacter pylori eradication result in clinical improvement and cur e as well as in long-term healing of ulcers.