T. Inaoka et al., Scintigraphic evaluation of pamidronate and corticosteroid therapy in a patient with progressive diaphyseal dysplasia (Camurati-Engelmann disease), CLIN NUCL M, 26(8), 2001, pp. 680-682
A 27-year-old woman with progressive diaphyseal dysplasia (Camurati-Engelma
nn disease) received pamidronate and corticosteroid therapy for bone pain.
During therapy, disease activity was assessed serially using bone scintigra
phy with Tc-99m HMDP. With pamidronate administration, the bone pain became
worse and diaphyseal uptake of Tc-99m HMDP increased whereas corticosteroi
d administration improved the bone pain and reduced the diaphyseal uptake.
In this case, pamidronate and corticosteroid produced different effects. Bo
ne scintigraphy allowed an objective assessment of the response to these tr
eatments, accurately reflecting clinical symptoms.