A polymorphic genomic duplication on human chromosome 15 is a susceptibility factor for panic and phobic disorders

Citation
M. Gratacos et al., A polymorphic genomic duplication on human chromosome 15 is a susceptibility factor for panic and phobic disorders, CELL, 106(3), 2001, pp. 367-379
Citations number
50
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cell & Developmental Biology
Journal title
CELL
ISSN journal
0092-8674 → ACNP
Volume
106
Issue
3
Year of publication
2001
Pages
367 - 379
Database
ISI
SICI code
0092-8674(20010810)106:3<367:APGDOH>2.0.ZU;2-I
Abstract
Anxiety disorders are complex and common psychiatric illnesses associated w ith considerable morbidity and social cost. We have studied the molecular b asis of the cooccurrence of panic and phobic disorders with joint laxity. W e have identified an interstitial duplication of human chromosome 15q24-26 (named DUP25), which is significantly associated with panic/agoraphobia/soc ial phobia/joint laxity in families, and with panic disorder in nonfamilial cases. Mosaicism, different forms of DUP25 within the same family, and abs ence of segregation of 15q24-26 markers with DUP25 and the psychiatric phen otypes suggest a non-Mendelian mechanism of disease-causing mutation. We pr opose that DUP25, which is present in 7% control subjects, is a susceptibil ity factor for a clinical phenotype that includes panic and phobic disorder s and joint laxity.