Validity of local treatment including intraarterial infusion chemotherapy and radiotherapy for fungating adenocarcinoma of the breast - Case report of more than 8-year survival

Citation
M. Murakami et al., Validity of local treatment including intraarterial infusion chemotherapy and radiotherapy for fungating adenocarcinoma of the breast - Case report of more than 8-year survival, AM J CL ONC, 24(4), 2001, pp. 388-391
Citations number
11
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
Journal title
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
ISSN journal
0277-3732 → ACNP
Volume
24
Issue
4
Year of publication
2001
Pages
388 - 391
Database
ISI
SICI code
0277-3732(200108)24:4<388:VOLTII>2.0.ZU;2-D
Abstract
A 39-year-old woman came to us complaining of severe anemia (hemoglobin: 2. 3 g/dl) and a painful right breast that was entirely occupied by an ulcerat ive, foul-smelling tumor approximately 20 cm in maximum dimension. The tumo r, which was determined to be mucinous adenocarcinoma at biopsy, had invade d the chest wall with multiple lung metastases (T4cN2M1 stage IV). After a blood transfusion, the patient received the following multimodal treatment: concurrent chemoradiotherapy (50 Gy), intraarterial infusion chemotherapy consisting of doxorubicin 50 mg, mitomycin-C 10 mg, and cisplatin 50 mg and skin graft surgery. After intraarterial infusion chemotherapy, the fungati ng tumor disappeared. The patient experienced a relapse of right pleural ef fusion 2 years later and received multimodal treatment. Now, March 30, 2000 , the patient is doing well without local recurrence, 8 years after her fir st admission. The combination of intraarterial infusion chemotherapy and ra diotherapy plays a role in successful treatment of extensive local disease of the breast.