Y. Kadoi et al., Time course of changes in jugular venous oxygen saturation during hypothermic or normothermic cardiopulmonary bypass in patients with diabetes mellitus, ACT ANAE SC, 45(7), 2001, pp. 858-862
Aneshtesia & Intensive Care","Medical Research Diagnosis & Treatment
Background: Preexisting diabetic mellitus is a risk factor determining post
operative neurological disorders. The present study assesses the effects of
normothermic and hypothermic cardiopulmonary bypass (CPB) on jugular venou
s oxygen saturation (SjvO(2))in patients with preexisting diabetic mellitus
Methods: Sixteen diabetic patients who underwent elective coronary artery b
ypass grafting surgery were randomly divided into two groups: Group DN (n=8
, diabetic patients) underwent normothermic CPB (> 35 degreesC), and group
DH (n=8, diabetic patients) underwent hypothermic CPB (32 degreesC). Contro
ls were 16 age-matched non-diabetic patients (normothermic group, CN: n=8;
hypothermic group, CH: n=8). A 4.0 F fiberoptic oximetry oxygen saturation
catheter was inserted into the right jugular bulb to continuously monitor S
jvO(2) values. Hemodynamic parameters and arterial and jugular venous blood
gases were measured seven times.
Results: Cerebral desaturation, which was defined as SjvO(2) values below 5
0%, was observed during normothermic CPB in diabetic patients (at the onset
of CPB: 46 +/-3%, at 20 min after onset of CPB: 49 +/-3%, means +/- SD, re
spectively). No cerebral desaturation occurred in diabetic and control pati
ents during hypothermic CPB.
Conclusions: Patients with preexisting diabetes mellitus experienced cerebr
al desaturation during normothermic CPB.