Time course of changes in jugular venous oxygen saturation during hypothermic or normothermic cardiopulmonary bypass in patients with diabetes mellitus

Citation
Y. Kadoi et al., Time course of changes in jugular venous oxygen saturation during hypothermic or normothermic cardiopulmonary bypass in patients with diabetes mellitus, ACT ANAE SC, 45(7), 2001, pp. 858-862
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Aneshtesia & Intensive Care","Medical Research Diagnosis & Treatment
Journal title
ACTA ANAESTHESIOLOGICA SCANDINAVICA
ISSN journal
0001-5172 → ACNP
Volume
45
Issue
7
Year of publication
2001
Pages
858 - 862
Database
ISI
SICI code
0001-5172(200108)45:7<858:TCOCIJ>2.0.ZU;2-Z
Abstract
Background: Preexisting diabetic mellitus is a risk factor determining post operative neurological disorders. The present study assesses the effects of normothermic and hypothermic cardiopulmonary bypass (CPB) on jugular venou s oxygen saturation (SjvO(2))in patients with preexisting diabetic mellitus . Methods: Sixteen diabetic patients who underwent elective coronary artery b ypass grafting surgery were randomly divided into two groups: Group DN (n=8 , diabetic patients) underwent normothermic CPB (> 35 degreesC), and group DH (n=8, diabetic patients) underwent hypothermic CPB (32 degreesC). Contro ls were 16 age-matched non-diabetic patients (normothermic group, CN: n=8; hypothermic group, CH: n=8). A 4.0 F fiberoptic oximetry oxygen saturation catheter was inserted into the right jugular bulb to continuously monitor S jvO(2) values. Hemodynamic parameters and arterial and jugular venous blood gases were measured seven times. Results: Cerebral desaturation, which was defined as SjvO(2) values below 5 0%, was observed during normothermic CPB in diabetic patients (at the onset of CPB: 46 +/-3%, at 20 min after onset of CPB: 49 +/-3%, means +/- SD, re spectively). No cerebral desaturation occurred in diabetic and control pati ents during hypothermic CPB. Conclusions: Patients with preexisting diabetes mellitus experienced cerebr al desaturation during normothermic CPB.