Optimisation of radiotherapy for carcinoma of the parotid gland: a comparison of conventional, three-dimensional conformal, and intensity-modulated techniques

Citation
Cm. Nutting et al., Optimisation of radiotherapy for carcinoma of the parotid gland: a comparison of conventional, three-dimensional conformal, and intensity-modulated techniques, RADIOTH ONC, 60(2), 2001, pp. 163-172
Citations number
47
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Onconogenesis & Cancer Research
Journal title
RADIOTHERAPY AND ONCOLOGY
ISSN journal
0167-8140 → ACNP
Volume
60
Issue
2
Year of publication
2001
Pages
163 - 172
Database
ISI
SICI code
0167-8140(200108)60:2<163:OORFCO>2.0.ZU;2-8
Abstract
Background and purpose: To compare external beam radiotherapy techniques fo r parotid gland tumours using conventional radiotherapy (RT), three-dimensi onal conformal radiotherapy (3DCRT), and intensity-modulated radiotherapy ( IMRT). To optimise the IMRT techniques, and to produce an IMRT class soluti on. Materials and methods: The planning target volume (PTV), contra-lateral par otid gland, oral cavity, brain-stern, brain and cochlea were outlined on CT planning scans of six patients with parotid gland tumours. Optimised conve ntional RT and 3DCRT plans were created and compared with inverse-planned I MRT dose distributions using dose-volume histograms. The aim was to reduce the radiation dose to organs at risk and improve the PTV dose distribution. A beam-direction optimisation algorithm was used to improve the dose distr ibution of the IMRT plans, and a class solution for parotid gland IMRT was investigated. Results: 3DCRT plans produced an equivalent PTV irradiation and reduced the dose to the cochlea, oral cavity, brain, and other normal tissues compared with conventional RT. IMRT further reduced the radiation dose to the cochl ea and oral cavity compared with 3DCRT. For nine- and seven-field IMRT tech niques, there was an increase in low-dose radiation to non-target tissue an d the contra-lateral parotid gland. IMRT plans produced using three to five optimised intensity-modulated beam directions maintained the advantages of the more complex IMRT plans, and reduced the contra-lateral parotid gland dose to acceptable levels. Three- and four-field non-coplanar beam arrangem ents increased the volume of brain irradiated, and increased PTV dose inhom ogeneity. A four-field class solution consisting of paired ipsilateral copl anar anterior and posterior oblique beams (15, 45, 145 and 170 degrees from the anterior plane) was developed which maintained the benefits without th e complexity of individual patient optimisation. Conclusions: For patients with parotid gland tumours, reduction in the radi ation dose to critical normal tissues was demonstrated with 3DCRT compared with conventional RT. IMRT produced a further reduction in the dose to the cochlea and oral cavity. With nine and seven fields, the dose to the contra -lateral parotid gland was increased, but this was avoided by optimisation of the beam directions. The benefits of IMRT were maintained with three or four fields when the beam angles were optimised, but were also achieved usi ng a four-field class solution. Clinical trials are required to confirm the clinical benefits of these improved dose distributions. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.