Effect of a low tryptophan diet on the prolactin responses to the 5-HT2A agonist DOI in the rat

Citation
M. Franklin et Pj. Cowen, Effect of a low tryptophan diet on the prolactin responses to the 5-HT2A agonist DOI in the rat, PHARMACOPS, 34(4), 2001, pp. 147-149
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
PHARMACOPSYCHIATRY
ISSN journal
0176-3679 → ACNP
Volume
34
Issue
4
Year of publication
2001
Pages
147 - 149
Database
ISI
SICI code
0176-3679(200107)34:4<147:EOALTD>2.0.ZU;2-Z
Abstract
Low tryptophan (TRP) diets decrease brain serotonin (5-HT) content and prod uce an up-regulation of the function of some but not all 5-HT receptor subt ypes. The aim of the present study was to assess the effect of a two week l ow TRP containing diet on the plasma prolactin (PRL) response to the 5-HT2A receptor agonist 2,5-dimethoxy-4-iodophenyl-2-aminopropane (DOI) in the ra t. The low TRP diet significantly reduced plasma total TRIP as well as brai n 5-HT for the two weeks of the study although plasma free TRIP was decreas ed only for the first week of the diet. The PRL response to DOI was signifi cantly increased in the first week of the diet but returned to normal in th e second. The results suggest that a low TRP diet produce a transient up-re gulation of brain 5-HT2A receptors.