Acute exposure to a low or mild dose of soman: Biochemical, behavioral andhistopathological effects

Citation
V. Baille et al., Acute exposure to a low or mild dose of soman: Biochemical, behavioral andhistopathological effects, PHARM BIO B, 69(3-4), 2001, pp. 561-569
Citations number
46
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
ISSN journal
0091-3057 → ACNP
Volume
69
Issue
3-4
Year of publication
2001
Pages
561 - 569
Database
ISI
SICI code
0091-3057(200107/08)69:3-4<561:AETALO>2.0.ZU;2-A
Abstract
Effects of low to mild doses of soman on central and blood cholinesterase ( ChE) activities and anxiety behavior were studied in mice 30 min, 24 h and 7 days after poisoning. At these two latter time points, histopathological consequences of soman intoxication were also studied. The 30-mug/kg dose of soman produced 30 min after intoxication, about 35% of central ChE inhibit ion, and an anxiolytic, effect without toxic signs or histopathological cha nges. The 50-mug/kg dose of soman produced at the same time, about 56% of c entral ChE inhibition, slight clinical signs of poisoning without convulsio ns, an anxiogenic effect with a slight hypolocomotion but no brain damage. A mild dose of soman (90 mug/kg) produced at this same time point about 80% of central ChE inhibition, and led to ataxia and tremors in every mouse an d to convulsions in some of them. Thirty minutes and 24 h after poisoning, the behavioral tests revealed neither anxiolytic nor anxiogenic responses d espite a clear hypolocomotion. Only mice that experienced long-lasting conv ulsions developed neuropathological changes. The functional implication of our results, as well as the biological relevance of blood vs. brain ChE lev els, as an index of intoxication severity are discussed. (C) 2001 Elsevier Science Inc. All rights reserved.