Intramolecular 1,3-dipolar cycloaddition strategy for enantioselective synthesis of FR-900482 analogues

Citation
M. Kambe et al., Intramolecular 1,3-dipolar cycloaddition strategy for enantioselective synthesis of FR-900482 analogues, ORG LETT, 3(16), 2001, pp. 2575-2578
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
1523-7060 → ACNP
Volume
3
Issue
16
Year of publication
2001
Pages
2575 - 2578
Database
ISI
SICI code
1523-7060(20010809)3:16<2575:I1CSFE>2.0.ZU;2-0
Abstract
[GRAPHICS] Enantioselective synthesis of FR-900482 analogues is described. The key rea ction of the synthesis is intramolecular 1,3-dipolar cycloaddition of a hig hly functionalized nitrile oxide with complete stereo- and regioselectiviti es to construct the eight-membered benzazocine ring.