Au. Trendelenburg et al., A study of presynaptic alpha(2)-autoreceptors in alpha(2A/D)-, alpha(2B)- and alpha(2C)-adrenoceptor-deficient mice, N-S ARCH PH, 364(2), 2001, pp. 117-130
The function of presynaptic alpha (2)-autoreceptors was studied in the hipp
ocampus, occipito-parietal cortex, atria and vas deferens of NMRI mice, mic
e in which the alpha (-)(2A/D), the alpha (2B-) or alpha (2C)-adrenoceptor
gene had been disrupted (alpha (2A)/DKO, alpha 2BKO and alpha 2CKO, respect
ively), and the wildtype mice from which the knockout animals had been gene
rated. Tissue pieces were preincubated with H-3-noradrenaline and then supe
rfused and stimulated electrically.