Schizophrenia and liver dysfunction

Authors
Citation
J. Kroll, Schizophrenia and liver dysfunction, MED HYPOTH, 56(5), 2001, pp. 634-636
Citations number
57
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research General Topics
Journal title
MEDICAL HYPOTHESES
ISSN journal
0306-9877 → ACNP
Volume
56
Issue
5
Year of publication
2001
Pages
634 - 636
Database
ISI
SICI code
0306-9877(200105)56:5<634:SALD>2.0.ZU;2-E
Abstract
It is suggested that a non-hepatocellular liver dysfunction, caused by the presence of a congenital or acquired portal-systemic shunt, constitutes a m ajor predisposing factor in the pathogenesis of schizophrenia. In addition to the common occurrence of schizophrenic reactions observed in liver disea se, this suggestion is supported by autoptic findings in addition to the fa ct that a considerable number of abnormal biochemical and biological phenom ena are shared by patients suffering from schizophrenia and portal-systemic shunting. The frequency of abnormal portal-systemic shunts in schizophreni a is unknown. Recent advances in non-invasive Doppler-sonographic technique s should enable an elucidation of this question. (C) 2001 Harcourt Publishe rs Ltd.