Mammalian Kruppel-like transcription factors include 12 zinc finger protein
s (KLF1-12) that are involved in regulation of cell proliferation and diffe
rentiation during morphogenesis and development (Trends Biochem. Sci., 24 (
1999) 236). Structural considerations have segregated KLF6 and KLF7 into a
separate sub-group, whereas in situ hybridizations have revealed predominan
t expression of the mouse klf7 gene in the developing nervous system. We ex
amined the embryonic pattern of mouse klf6 in order to assess whether close
kinship between KLF6 and KLF7 reflects similar expression patterns of the
genes. The results of the in situ hybridizations demonstrate that klf6 expr
ession in the developing nervous system is more restricted than klf7. In co
ntrast to kr, we also identified several non-neural sites of strong klf6 ex
pression they include the developing hindgut, heart, lung, kidney, and auto
pod. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.