Embryonic expression of Kruppel-like factor 6 in neural and non-neural tissues

Citation
F. Laub et al., Embryonic expression of Kruppel-like factor 6 in neural and non-neural tissues, MECH DEVEL, 106(1-2), 2001, pp. 167-170
Citations number
7
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cell & Developmental Biology
Journal title
MECHANISMS OF DEVELOPMENT
ISSN journal
0925-4773 → ACNP
Volume
106
Issue
1-2
Year of publication
2001
Pages
167 - 170
Database
ISI
SICI code
0925-4773(200108)106:1-2<167:EEOKF6>2.0.ZU;2-7
Abstract
Mammalian Kruppel-like transcription factors include 12 zinc finger protein s (KLF1-12) that are involved in regulation of cell proliferation and diffe rentiation during morphogenesis and development (Trends Biochem. Sci., 24 ( 1999) 236). Structural considerations have segregated KLF6 and KLF7 into a separate sub-group, whereas in situ hybridizations have revealed predominan t expression of the mouse klf7 gene in the developing nervous system. We ex amined the embryonic pattern of mouse klf6 in order to assess whether close kinship between KLF6 and KLF7 reflects similar expression patterns of the genes. The results of the in situ hybridizations demonstrate that klf6 expr ession in the developing nervous system is more restricted than klf7. In co ntrast to kr, we also identified several non-neural sites of strong klf6 ex pression they include the developing hindgut, heart, lung, kidney, and auto pod. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.